Advanced Pharmacology Prednisone for COPD

Advanced Pharmacology Prednisone for COPD

Advanced Pharmacology Prednisone for COPD

Pharmacodynamics: Prednisone

Prednisone is a synthetic glucocorticoid indicated to implicate human cortisone. It acts by binding on glucocorticoid receptors in the cell nucleus hence initiating change in the gene expression that sustain effects for hours or days (Puckett, Gabbar & Bokhari, 2020 Advanced Pharmacology Prednisone for COPD). It therefore exhibits anti-inflammatory characteristics in low doses and immunomodulating effects in high doses. It has a short half-life of about 2 to 3 hours, hence require multiple doses to keep the cortisone levels up. The clinician should caution the patient on possible hypothalamic features due to artificial supplementation of cortisone produced by adrenal glands.

Advanced Pharmacology Prednisone for COPD

Metabolization of Prednisone occurs in the liver to form prednisolone. Excretion of the metabolites occurs through urine, with a clearance of about 0.09l/kg/h to 0.12l/kg/h. It reduces metabolism of Acarbose, hence increasing chances of hyperglycemia when used together (Schijvens et al, 2019 Advanced Pharmacology Prednisone for COPD). Other possible interactions are with phenytoin, barbiturates, and rifampin, drugs associated with increased metabolism (Yasir, Goyal & Bansal, 2021). Possible side effects include increased susceptibility to infections due to suppressed immunity, heartburn, insomnia, headache, nausea, dizziness and menstrual period changes.

The nurse should monitor such clinical signs as fever and interrupted healing. Further, Corticosteroids are likely to trigger infections caused by pathogens. The nurse should therefore observe for and report exacerbations. The clinician should educate the family and patient should on the need for regimen compliance, with strict rules not to change the dosage (Hodgens & Sharman, 2020 Advanced Pharmacology Prednisone for COPD). Encourage the patient to report cases of gastric distress or signs of peptic ulcers. The drug in placed in pregnancy category C, hence should not be used among lactating mothers. The clinician should also discourage the patient from using other over the counter medications to reduce the risks for possible negative interactions with prednisone.

Advanced Pharmacology Prednisone for COPD References

Instructions

***POWERPOINT PRESENTATION***
TOPIC: Prednisone for COPDThe presentation must identify the Pharmacodynamic properties and actual/potential effects on the patient. The pharmacodynamics of a med should be the discussion about how the med is metabolized, excreted, the half life, etc. This needs to be a thorough discussion about the medication assigned.
Nursing Implications are the nursing related consequences and what you as the nurse should be looking for in the treatment and care of your patient- these should be included.
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